Names & Taxonomy
- Uniprot ID:
- Q9H222
- Entry Name:
- ABCG5_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-binding cassette sub-family G member 5 (Sterolin-1)
- Gene Names:
- ABCG5
- Gene Names Primary:
- ABCG5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 651
- Sequence:
- MGDLSSLTPGGSMGLQVNRGSQSSLEGAPATAPEPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLISR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
- Cross Reference Drug Bank:
- DB00973
- Gene Ontology Go:
- apical plasma membrane
ATP-binding cassette (ABC) transporter complex
plasma membrane
receptor complex
ATP binding
ATPase activity, coupled to transmembrane movement of substances
cholesterol transporter activity
protein heterodimerization activity
cholesterol efflux
cholesterol homeostasis
excretion
intestinal cholesterol absorption
negative regulation of intestinal cholesterol absorption
negative regulation of intestinal phytosterol absorption
response to drug
response to ionizing radiation
response to nutrient
small molecule metabolic process
sterol transport
transmembrane transport - Gene Ontology Biological Process:
- cholesterol efflux
cholesterol homeostasis
excretion
intestinal cholesterol absorption
negative regulation of intestinal cholesterol absorption
negative regulation of intestinal phytosterol absorption
response to drug
response to ionizing radiation
response to nutrient
small molecule metabolic process
sterol transport
transmembrane transport - Gene Ontology Molecular Function:
- ATPase activity, coupled to transmembrane movement of substances
ATP binding
cholesterol transporter activity
protein heterodimerization activity - Gene Ontology Cellular Component:
- apical plasma membrane
ATP-binding cassette (ABC) transporter complex
plasma membrane
receptor complex - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q9H221; P16333