Names & Taxonomy

Uniprot ID:
Q9H221
Entry Name:
ABCG8_HUMAN
Status:
reviewed
Protein Names:
ATP-binding cassette sub-family G member 8 (Sterolin-2)
Gene Names:
ABCG8
Gene Names Primary:
ABCG8
Organism:
Homo sapiens (Human)

Structure

Length:
673
Sequence:
MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRFIKQKPSQDW
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Cross Reference Drug Bank:
DB00973
Gene Ontology Go:
apical plasma membrane
ATP-binding cassette (ABC) transporter complex
plasma membrane
receptor complex
ATP binding
ATPase activity, coupled to transmembrane movement of substances
cholesterol transporter activity
protein heterodimerization activity
cholesterol efflux
cholesterol homeostasis
excretion
intestinal cholesterol absorption
negative regulation of intestinal cholesterol absorption
negative regulation of intestinal phytosterol absorption
phospholipid transport
response to drug
response to nutrient
small molecule metabolic process
sterol transport
transmembrane transport
Gene Ontology Biological Process:
cholesterol efflux
cholesterol homeostasis
excretion
intestinal cholesterol absorption
negative regulation of intestinal cholesterol absorption
negative regulation of intestinal phytosterol absorption
phospholipid transport
response to drug
response to nutrient
small molecule metabolic process
sterol transport
transmembrane transport
Gene Ontology Molecular Function:
ATPase activity, coupled to transmembrane movement of substances
ATP binding
cholesterol transporter activity
protein heterodimerization activity
Gene Ontology Cellular Component:
apical plasma membrane
ATP-binding cassette (ABC) transporter complex
plasma membrane
receptor complex
Keywords:
Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q9H222

Publication

PubMed ID:
11099417 11452359 15815621 11590207 24275569 11668628 12111378 17632509