Names & Taxonomy

Uniprot ID:
Q9H015
Entry Name:
S22A4_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (Organic cation/carnitine transporter 1)
Gene Names:
SLC22A4 ETT OCTN1 UT2H
Gene Names Primary:
SLC22A4
Organism:
Homo sapiens (Human)

Structure

Length:
551
Sequence:
MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.470 mM for TEA (at 37 degrees Celsius and pH 7.4)
Cross Reference Drug Bank:
DB00594 DB00345 DB01053 DB00122 DB00501 DB00575 DB01151 DB00536 DB00458 DB00332 DB00125 DB00583 DB00123 DB01137 DB06691 DB00184 DB01165 DB01035 DB00908 DB00468 DB00127 DB00624 DB01409 DB00661
Gene Ontology Go:
apical plasma membrane
integral component of plasma membrane
mitochondrion
plasma membrane
ATP binding
carnitine transmembrane transporter activity
cation:cation antiporter activity
nucleotide binding
PDZ domain binding
quaternary ammonium group transmembrane transporter activity
secondary active organic cation transmembrane transporter activity
symporter activity
body fluid secretion
carnitine metabolic process
carnitine transmembrane transport
carnitine transport
cation transmembrane transport
organic cation transport
quaternary ammonium group transport
sodium ion transport
transmembrane transport
triglyceride metabolic process
Gene Ontology Biological Process:
body fluid secretion
carnitine metabolic process
carnitine transmembrane transport
carnitine transport
cation transmembrane transport
organic cation transport
quaternary ammonium group transport
sodium ion transport
transmembrane transport
triglyceride metabolic process
Gene Ontology Molecular Function:
ATP binding
carnitine transmembrane transporter activity
cation:cation antiporter activity
nucleotide binding
PDZ domain binding
quaternary ammonium group transmembrane transporter activity
secondary active organic cation transmembrane transporter activity
symporter activity
Gene Ontology Cellular Component:
apical plasma membrane
integral component of plasma membrane
mitochondrion
plasma membrane
Keywords:
ATP-binding
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9426230 15795384 15372022 15489334 10215651 14608356 12436193 15459889 15107849