Names & Taxonomy
- Uniprot ID:
- Q9GZZ6
- Entry Name:
- ACH10_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)
- Gene Names:
- CHRNA10 NACHRA10
- Gene Names Primary:
- CHRNA10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 450
- Sequence:
- MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane
Function
- Function:
- Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
- Cross Reference Drug Bank:
- DB01161 DB00898 DB00674 DB00333 DB00184 DB01090 DB00202 DB01116
- Gene Ontology Go:
- acetylcholine-gated channel complex
axon
cell junction
membrane
perikaryon
postsynaptic membrane
acetylcholine binding
acetylcholine-activated cation-selective channel activity
calcium channel activity
receptor binding
chemical synaptic transmission, postsynaptic
detection of mechanical stimulus involved in sensory perception of sound
inner ear morphogenesis
positive regulation of cytosolic calcium ion concentration
regulation of cell proliferation
signal transduction
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- chemical synaptic transmission, postsynaptic
detection of mechanical stimulus involved in sensory perception of sound
inner ear morphogenesis
positive regulation of cytosolic calcium ion concentration
regulation of cell proliferation
signal transduction
synaptic transmission, cholinergic - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine binding
calcium channel activity
receptor binding - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
axon
cell junction
membrane
perikaryon
postsynaptic membrane - Keywords:
- Calcium
Calcium channel
Calcium transport
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport