Names & Taxonomy

Uniprot ID:
Q9BZV2
Entry Name:
S19A3_HUMAN
Status:
reviewed
Protein Names:
Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)
Gene Names:
SLC19A3
Gene Names Primary:
SLC19A3
Organism:
Homo sapiens (Human)

Structure

Length:
496
Sequence:
MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity.
Cross Reference Drug Bank:
DB00151
Gene Ontology Go:
integral component of membrane
integral component of plasma membrane
plasma membrane
thiamine uptake transmembrane transporter activity
small molecule metabolic process
thiamine transmembrane transport
thiamine-containing compound metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Biological Process:
small molecule metabolic process
thiamine-containing compound metabolic process
thiamine transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Molecular Function:
thiamine uptake transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of membrane
integral component of plasma membrane
plasma membrane
Keywords:
Complete proteome
Disease mutation
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
11136550 15815621 15489334 11731220 14770311 19159218 24275569 15871139