Names & Taxonomy
- Uniprot ID:
- Q9BZC1
- Entry Name:
- CELF4_HUMAN
- Status:
- reviewed
- Protein Names:
- CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4)
- Gene Names:
- CELF4 BRUNOL4
- Gene Names Primary:
- CELF4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 486
- Sequence:
- MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPFGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
- Gene Ontology Go:
- cytoplasm
nucleus
BRE binding
mRNA binding
nucleotide binding
translation repressor activity, nucleic acid binding
alternative mRNA splicing, via spliceosome
embryo development
germ cell development
mRNA splice site selection
negative regulation of excitatory postsynaptic potential
negative regulation of mRNA splicing, via spliceosome
negative regulation of translation
positive regulation of mRNA splicing, via spliceosome
regulation of alternative mRNA splicing, via spliceosome - Gene Ontology Biological Process:
- alternative mRNA splicing, via spliceosome
embryo development
germ cell development
mRNA splice site selection
negative regulation of excitatory postsynaptic potential
negative regulation of mRNA splicing, via spliceosome
negative regulation of translation
positive regulation of mRNA splicing, via spliceosome
regulation of alternative mRNA splicing, via spliceosome - Gene Ontology Molecular Function:
- BRE binding
mRNA binding
nucleotide binding
translation repressor activity, nucleic acid binding - Gene Ontology Cellular Component:
- cytoplasm
nucleus - Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
Cytoplasm
Nucleus
Polymorphism
RNA-binding
Reference proteome
Repeat
mRNA processing
mRNA splicing