Names & Taxonomy
- Uniprot ID:
- Q9BYT9
- Entry Name:
- ANO3_HUMAN
- Status:
- reviewed
- Protein Names:
- Anoctamin-3 (Transmembrane protein 16C)
- Gene Names:
- ANO3 C11orf25 TMEM16C GENX-3947
- Gene Names Orf:
- GENX-3947
- Gene Names Primary:
- ANO3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 981
- Sequence:
- MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSTESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQQQRRKSGQPVHHEWP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity.
- Gene Ontology Go:
- integral component of membrane
plasma membrane
phospholipid scramblase activity
calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
detection of mechanical stimulus
detection of temperature stimulus
ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
detection of mechanical stimulus
detection of temperature stimulus
ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- phospholipid scramblase activity
- Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Dystonia
Glycoprotein
Lipid transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport