Names & Taxonomy
- Uniprot ID:
- Q9BYF1
- Entry Name:
- ACE2_HUMAN
- Status:
- reviewed
- Protein Names:
- Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin-converting enzyme homolog) (ACEH) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]
- Gene Names:
- ACE2 UNQ868/PRO1885
- Gene Names Orf:
- UNQ868/PRO1885
- Gene Names Primary:
- ACE2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 805
- Sequence:
- MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Processed angiotensin-converting enzyme 2: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm
Function
- Function:
- Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function.
- Catalytic Activity:
- Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.9 uM for angiotensin I
- Enzyme Regulation:
- ENZYME REGULATION: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat.
- Active Site:
- ACT_SITE 375 375; ACT_SITE 505 505
- Cross Reference Drug Bank:
- DB00722 DB00691
- Gene Ontology Go:
- cell surface
cytoplasm
extracellular exosome
extracellular region
extracellular space
integral component of membrane
membrane raft
plasma membrane
carboxypeptidase activity
endopeptidase activity
glycoprotein binding
virus receptor activity
zinc ion binding
angiotensin catabolic process in blood
angiotensin maturation
angiotensin-mediated drinking behavior
cellular protein metabolic process
positive regulation of cardiac muscle contraction
positive regulation of gap junction assembly
positive regulation of reactive oxygen species metabolic process
receptor biosynthetic process
receptor-mediated virion attachment to host cell
regulation of cardiac conduction
regulation of cell proliferation
regulation of cytokine production
regulation of inflammatory response
regulation of systemic arterial blood pressure by renin-angiotensin
regulation of vasoconstriction
regulation of vasodilation
tryptophan transport
viral entry into host cell - Gene Ontology Biological Process:
- angiotensin catabolic process in blood
angiotensin maturation
angiotensin-mediated drinking behavior
cellular protein metabolic process
positive regulation of cardiac muscle contraction
positive regulation of gap junction assembly
positive regulation of reactive oxygen species metabolic process
receptor biosynthetic process
receptor-mediated virion attachment to host cell
regulation of cardiac conduction
regulation of cell proliferation
regulation of cytokine production
regulation of inflammatory response
regulation of systemic arterial blood pressure by renin-angiotensin
regulation of vasoconstriction
regulation of vasodilation
tryptophan transport
viral entry into host cell - Gene Ontology Molecular Function:
- carboxypeptidase activity
endopeptidase activity
glycoprotein binding
virus receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- cell surface
cytoplasm
extracellular exosome
extracellular region
extracellular space
integral component of membrane
membrane raft
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Carboxypeptidase
Cell membrane
Chloride
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Hydrolase
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Receptor
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc