Names & Taxonomy
- Uniprot ID:
- Q9BYC2
- Entry Name:
- SCOT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 2A) (Testis-specific succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-t)
- Gene Names:
- OXCT2 FKSG25
- Gene Names Orf:
- FKSG25
- Gene Names Primary:
- OXCT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 517
- Sequence:
- MAALRLLASVLGRGVPAGGSGLALSQGCARCFATSPRLRAKFYADPVEMVKDISDGATVMIGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGVEDFGLGLLLAARQVRRIVCSYVGENTLCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGAPIRYTPDGHLALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRAGNVVFRRSARNFNVPMCKAADVTAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYEKRIERLTILKEEDGDAGKEEDARTRIIRRAALEFEDGMYANLGIGIPLLASNFISPSMTVHLHSENGILGLGPFPTEDEVDADLINAGKQTVTVLPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMIPGKKVKGMGGAMDLVSSQKTRVVVTMQHCTKDNTPKIMEKCTMPLTGKRCVDRIITEKAVFDVHRKKELTLRELWEGLTVDDIKKSTGCAFAVSPNLRPMQQVAP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).
- Pathway:
- Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.
- Catalytic Activity:
- Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
- Active Site:
- ACT_SITE 341 341 5-glutamyl coenzyme A thioester intermediate.
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- mitochondrion
motile cilium
3-oxoacid CoA-transferase activity
ketone body catabolic process - Gene Ontology Biological Process:
- ketone body catabolic process
- Gene Ontology Molecular Function:
- 3-oxoacid CoA-transferase activity
- Gene Ontology Cellular Component:
- mitochondrion
motile cilium - Keywords:
- Complete proteome
Mitochondrion
Polymorphism
Reference proteome
Transferase
Transit peptide