Names & Taxonomy
- Uniprot ID:
- Q9BXS9
- Entry Name:
- S26A6_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)
- Gene Names:
- SLC26A6
- Gene Names Primary:
- SLC26A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 759
- Sequence:
- MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Apical cell membrane
Function
- Function:
- Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.; Isoform 4: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.
- Enzyme Regulation:
- ENZYME REGULATION: Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and oxalate secretion in the duodenum are inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters) (By similarity). Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). Isoform 4, isoform 5 and isoform 6 chloride, bicarbonate and sulfate transport activities are inhibited by DIDS.
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
chloride channel complex
cytoplasmic vesicle membrane
endoplasmic reticulum
integral component of membrane
integral component of plasma membrane
intracellular
membrane
membrane-bounded vesicle
plasma membrane
sperm midpiece
vesicle membrane
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
chloride transmembrane transporter activity
efflux transmembrane transporter activity
formate efflux transmembrane transporter activity
formate transmembrane transporter activity
formate uptake transmembrane transporter activity
oxalate transmembrane transporter activity
PDZ domain binding
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
angiotensin-activated signaling pathway
anion transmembrane transport
bicarbonate transport
cellular response to cAMP
cellular response to fructose stimulus
cellular response to interferon-gamma
chloride transmembrane transport
chloride transport
epithelial fluid transport
formate transport
intestinal absorption
intracellular pH elevation
ion transport
mannitol transport
oxalate transport
oxalic acid secretion
positive regulation of dipeptide transmembrane transport
protein kinase C signaling
regulation of intracellular pH
regulation of membrane potential
sperm capacitation
sulfate transmembrane transport
sulfate transport
transepithelial chloride transport
transepithelial transport
transmembrane transport - Gene Ontology Biological Process:
- angiotensin-activated signaling pathway
anion transmembrane transport
bicarbonate transport
cellular response to cAMP
cellular response to fructose stimulus
cellular response to interferon-gamma
chloride transmembrane transport
chloride transport
epithelial fluid transport
formate transport
intestinal absorption
intracellular pH elevation
ion transport
mannitol transport
oxalate transport
oxalic acid secretion
positive regulation of dipeptide transmembrane transport
protein kinase C signaling
regulation of intracellular pH
regulation of membrane potential
sperm capacitation
sulfate transmembrane transport
sulfate transport
transepithelial chloride transport
transepithelial transport
transmembrane transport - Gene Ontology Molecular Function:
- anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
chloride transmembrane transporter activity
efflux transmembrane transporter activity
formate efflux transmembrane transporter activity
formate transmembrane transporter activity
formate uptake transmembrane transporter activity
oxalate transmembrane transporter activity
PDZ domain binding
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
brush border membrane
chloride channel complex
cytoplasmic vesicle membrane
endoplasmic reticulum
integral component of membrane
integral component of plasma membrane
intracellular
membrane
membrane-bounded vesicle
plasma membrane
sperm midpiece
vesicle membrane - Keywords:
- Alternative splicing
Anion exchange
Antiport
Cell membrane
Chloride
Chloride channel
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Ion channel
Ion transport
Membrane
Microsome
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport