Names & Taxonomy
- Uniprot ID:
- Q9BXJ7
- Entry Name:
- AMNLS_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein amnionless
- Gene Names:
- AMN UNQ513/PRO1028
- Gene Names Orf:
- UNQ513/PRO1028
- Gene Names Primary:
- AMN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 453
- Sequence:
- MGVLGRVLLWLQLCALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGELVLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESGAHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELPLPRRLSLVPKAAADSTSHSYFVNPLFAGAEAEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity).
- Cross Reference Drug Bank:
- DB00115 DB00200
- Gene Ontology Go:
- apical plasma membrane
endocytic vesicle
endosome membrane
extracellular exosome
extracellular space
integral component of membrane
plasma membrane
receptor binding
cobalamin metabolic process
cobalamin transport
excretion
Golgi to plasma membrane protein transport
lipoprotein metabolic process
multicellular organism development
receptor-mediated endocytosis
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- cobalamin metabolic process
cobalamin transport
excretion
Golgi to plasma membrane protein transport
lipoprotein metabolic process
multicellular organism development
receptor-mediated endocytosis
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- receptor binding
- Gene Ontology Cellular Component:
- apical plasma membrane
endocytic vesicle
endosome membrane
extracellular exosome
extracellular space
integral component of membrane
plasma membrane - Keywords:
- Alternative promoter usage
Cell membrane
Coated pit
Complete proteome
Developmental protein
Direct protein sequencing
Disease mutation
Endosome
Glycoprotein
Membrane
Protein transport
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport