Names & Taxonomy

Uniprot ID:
Q9BWD1
Entry Name:
THIC_HUMAN
Status:
reviewed
Protein Names:
Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)
Gene Names:
ACAT2 ACTL
Gene Names Primary:
ACAT2
Organism:
Homo sapiens (Human)

Structure

Length:
397
Sequence:
MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGHVLAAGCGQNPVRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAGGMENMSKAPHLAYLRTGVKIGEMPLTDSILCDGLTDAFHNCHMGITAENVAKKWQVSREDQDKVAVLSQNRTENAQKAGHFDKEIVPVLVSTRKGLIEVKTDEFPRHGSNIEAMSKLKPYFLTDGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGPIPAIKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGASGCRILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQRE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Catalytic Activity:
2 acetyl-CoA = CoA + acetoacetyl-CoA.
Active Site:
ACT_SITE 92 92 Acyl-thioester intermediate.; ACT_SITE 353 353 Proton acceptor.; ACT_SITE 383 383 Proton acceptor.
Gene Ontology Go:
cytoplasm
extracellular exosome
nucleolus
nucleus
acetyl-CoA C-acetyltransferase activity
lipid metabolic process
Gene Ontology Biological Process:
lipid metabolic process
Gene Ontology Molecular Function:
acetyl-CoA C-acetyltransferase activity
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
nucleolus
nucleus
Keywords:
3D-structure
Acetylation
Acyltransferase
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Polymorphism
Reference proteome
Transferase
Interacts With:
Q8TBB1; P54274

Publication

PubMed ID:
7911016 14702039 14574404 15489334 19413330 19608861 21269460 22223895 22814378 24275569 25944712 15733928