Names & Taxonomy

Uniprot ID:
Q9BW92
Entry Name:
SYTM_HUMAN
Status:
reviewed
Protein Names:
Threonine--tRNA ligase, mitochondrial (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like 1)
Gene Names:
TARS2 TARSL1
Gene Names Primary:
TARS2
Organism:
Homo sapiens (Human)

Structure

Length:
718
Sequence:
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISSTLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPVLERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSNSSSLWRSSGAPETLQRVSGISFPTTELLRVWEAWREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIRAEYAHRGFSEVKTPTLFSTKLWEQSGHWEHYQEDMFAVQPPGSDRPPSSQSDDSTRHITDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGGLGGLTRLRCFQQDDAHIFCTTDQLEAEIQSCLDFLRSVYAVLGFSFRLALSTRPSGFLGDPCLWDQAEQVLKQALKEFGEPWDLNSGDGAFYGPKIDVHLHDALGRPHQCGTIQLDFQLPLRFDLQYKGQAGALERPVLIHRAVLGSVERLLGVLAESCGGKWPLWLSPFQVVVIPVGSEQEEYAKEAQQSLRAAGLVSDLDADSGLTLSRRIRRAQLAHYNFQFVVGQKEQSKRTVNIRTRDNRRLGEWDLPEAVQRLVELQNTRVPNAEEIF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix

Function

Catalytic Activity:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
Cross Reference Drug Bank:
DB00156
Gene Ontology Go:
mitochondrial matrix
ATP binding
threonine-tRNA ligase activity
gene expression
mitochondrial threonyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Biological Process:
gene expression
mitochondrial threonyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
Gene Ontology Molecular Function:
ATP binding
threonine-tRNA ligase activity
Gene Ontology Cellular Component:
mitochondrial matrix
Keywords:
ATP-binding
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Disease mutation
Ligase
Mitochondrion
Nucleotide-binding
Phosphoprotein
Protein biosynthesis
Reference proteome
Transit peptide

Publication

PubMed ID:
14702039 16710414 15489334 15779907 21269460 21406692 24827421 25944712