Names & Taxonomy
- Uniprot ID:
- Q9BVM4
- Entry Name:
- GGACT_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-glutamylaminecyclotransferase (GGACT) (EC 2.3.2.4) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase)
- Gene Names:
- GGACT A2LD1
- Gene Names Primary:
- GGACT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 153
- Sequence:
- MALVFVYGTLKRGQPNHRVLRDGAHGSAAFRARGRTLEPYPLVIAGEHNIPWLLHLPGSGRLVEGEVYAVDERMLRFLDDFESCPALYQRTVLRVQLLEDRAPGAEEPPAPTAVQCFVYSRATFPPEWAQLPHHDSYDSEGPHGLRYNPRENR
- Proteomes:
- UP000005640
Function
- Function:
- Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by transglutaminases. Catalyzes the formation of 5-oxoproline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.
- Catalytic Activity:
- (Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.
- Active Site:
- ACT_SITE 82 82 Proton acceptor.
- Gene Ontology Go:
- extracellular exosome
gamma-glutamylcyclotransferase activity
cellular modified amino acid catabolic process - Gene Ontology Biological Process:
- cellular modified amino acid catabolic process
- Gene Ontology Molecular Function:
- gamma-glutamylcyclotransferase activity
- Gene Ontology Cellular Component:
- extracellular exosome
- Keywords:
- 3D-structure
Acyltransferase
Complete proteome
Reference proteome
Transferase - Interacts With:
- Q96KN8-3