Names & Taxonomy
- Uniprot ID:
- Q9BVG9
- Entry Name:
- PTSS2_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II)
- Gene Names:
- PTDSS2 PSS2
- Gene Names Primary:
- PTDSS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 487
- Sequence:
- MRRGERRDAGGPRPESPVPAGRASLEEPPDGPSAGQATGPGEGRRSTESEVYDDGTNTFFWRAHTLTVLFILTCTLGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRPHPAYWRFWLCVSVVYELFLIFILFQTVQDGRQFLKYVDPKLGVPLPERDYGGNCLIYDPDNETDPFHNIWDKLDGFVPAHFLGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSECWWDHWIMDVLVCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSWVRFEWKPASSLRRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGVAMREIYDFMDDPKPHKKLGPQAWLVAAITATELLIVVKYDPHTLTLSLPFYISQCWTLGSVLALTWTVWRFFLRDITLRYKETRWQKWQNKDDQGSTVGNGDQHPLGLDEDLLGPGVAEGEGAPTPN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine.
- Pathway:
- Phospholipid metabolism; phosphatidylserine biosynthesis.
- Catalytic Activity:
- L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=120 uM for serine (in the presence of 1 mM PE)
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited in both the MAM and the ER per se by ethanolamine. Requires calcium ions.
- Cross Reference Drug Bank:
- DB00144
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
membrane
CDP-diacylglycerol-serine O-phosphatidyltransferase activity
glycerophospholipid biosynthetic process
phosphatidylserine biosynthetic process
phospholipid biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
phosphatidylserine biosynthetic process
phospholipid biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- CDP-diacylglycerol-serine O-phosphatidyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
membrane - Keywords:
- Complete proteome
Endoplasmic reticulum
Glycoprotein
Lipid biosynthesis
Lipid metabolism
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Reference proteome
Transferase
Transmembrane
Transmembrane helix