Names & Taxonomy

Uniprot ID:
Q9BQB6
Entry Name:
VKOR1_HUMAN
Status:
reviewed
Protein Names:
Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1)
Gene Names:
VKORC1 VKOR MSTP134 MSTP576 UNQ308/PRO351
Gene Names Orf:
MSTP134 MSTP576 UNQ308/PRO351
Gene Names Primary:
VKORC1
Organism:
Homo sapiens (Human)

Structure

Length:
163
Sequence:
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Catalytic Activity:
Phylloquinone + oxidized dithiothreitol + H(2)O = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by warfarin (coumadin).
Cross Reference Drug Bank:
DB01418 DB00266 DB00170 DB00498 DB00946 DB00682
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
quinone binding
vitamin-K-epoxide reductase (warfarin-sensitive) activity
blood coagulation
bone development
drug metabolic process
fat-soluble vitamin metabolic process
peptidyl-glutamic acid carboxylation
small molecule metabolic process
vitamin K metabolic process
vitamin metabolic process
Gene Ontology Biological Process:
blood coagulation
bone development
drug metabolic process
fat-soluble vitamin metabolic process
peptidyl-glutamic acid carboxylation
small molecule metabolic process
vitamin K metabolic process
vitamin metabolic process
Gene Ontology Molecular Function:
quinone binding
vitamin-K-epoxide reductase (warfarin-sensitive) activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
Keywords:
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Endoplasmic reticulum
Membrane
Oxidoreductase
Quinone
Redox-active center
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
14765194 14765195 14702039 15616553 15489334 12975309 15276181 15879509 15716279 16270630 20696932 20978134 22923610 24406068 20946155