Names & Taxonomy
- Uniprot ID:
- Q99835
- Entry Name:
- SMO_HUMAN
- Status:
- reviewed
- Protein Names:
- Smoothened homolog (SMO) (Protein Gx)
- Gene Names:
- SMO SMOH
- Gene Names Primary:
- SMO
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 787
- Sequence:
- MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
- Cross Reference Drug Bank:
- DB01047 DB09143 DB08828
- Gene Ontology Go:
- ciliary membrane
ciliary tip
endocytic vesicle membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
primary cilium
drug binding
G-protein coupled receptor activity
patched binding
Wnt-protein binding
anterior/posterior pattern specification
astrocyte activation
atrial septum morphogenesis
cell fate specification
cellular response to cholesterol
central nervous system neuron differentiation
cerebellar cortex morphogenesis
cerebral cortex development
dentate gyrus development
detection of cell density by contact stimulus involved in contact inhibition
determination of left/right asymmetry in lateral mesoderm
dorsal/ventral neural tube patterning
epithelial-mesenchymal cell signaling
forebrain morphogenesis
hair follicle morphogenesis
heart looping
homeostasis of number of cells within a tissue
in utero embryonic development
left/right axis specification
mammary gland epithelial cell differentiation
mesenchymal to epithelial transition involved in metanephric renal vesicle formation
midgut development
multicellular organism growth
myoblast migration
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of epithelial cell differentiation
negative regulation of gene expression
negative regulation of hair follicle development
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
odontogenesis of dentin-containing tooth
osteoblast differentiation
pancreas morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of gene expression
positive regulation of hh target transcription factor activity
positive regulation of mesenchymal cell proliferation
positive regulation of multicellular organism growth
positive regulation of neuroblast proliferation
positive regulation of organ growth
positive regulation of protein import into nucleus
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
protein localization to nucleus
protein stabilization
regulation of heart morphogenesis
regulation of stem cell population maintenance
renal system development
skeletal muscle fiber development
smoothened signaling pathway
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
smoothened signaling pathway involved in ventral spinal cord patterning
somite development
thalamus development
type B pancreatic cell development
vasculogenesis
ventral midline determination - Gene Ontology Biological Process:
- anterior/posterior pattern specification
astrocyte activation
atrial septum morphogenesis
cell fate specification
cellular response to cholesterol
central nervous system neuron differentiation
cerebellar cortex morphogenesis
cerebral cortex development
dentate gyrus development
detection of cell density by contact stimulus involved in contact inhibition
determination of left/right asymmetry in lateral mesoderm
dorsal/ventral neural tube patterning
epithelial-mesenchymal cell signaling
forebrain morphogenesis
hair follicle morphogenesis
heart looping
homeostasis of number of cells within a tissue
in utero embryonic development
left/right axis specification
mammary gland epithelial cell differentiation
mesenchymal to epithelial transition involved in metanephric renal vesicle formation
midgut development
multicellular organism growth
myoblast migration
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of epithelial cell differentiation
negative regulation of gene expression
negative regulation of hair follicle development
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
odontogenesis of dentin-containing tooth
osteoblast differentiation
pancreas morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of gene expression
positive regulation of hh target transcription factor activity
positive regulation of mesenchymal cell proliferation
positive regulation of multicellular organism growth
positive regulation of neuroblast proliferation
positive regulation of organ growth
positive regulation of protein import into nucleus
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
protein localization to nucleus
protein stabilization
regulation of heart morphogenesis
regulation of stem cell population maintenance
renal system development
skeletal muscle fiber development
smoothened signaling pathway
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
smoothened signaling pathway involved in ventral spinal cord patterning
somite development
thalamus development
type B pancreatic cell development
vasculogenesis
ventral midline determination - Gene Ontology Molecular Function:
- drug binding
G-protein coupled receptor activity
patched binding
Wnt-protein binding - Gene Ontology Cellular Component:
- ciliary membrane
ciliary tip
endocytic vesicle membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
primary cilium - Keywords:
- 3D-structure
Cell projection
Complete proteome
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix