Names & Taxonomy
- Uniprot ID:
- Q99808
- Entry Name:
- S29A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)
- Gene Names:
- SLC29A1 ENT1
- Gene Names Primary:
- SLC29A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 456
- Sequence:
- MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells.
Function
- Function:
- Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=0.62 mM for adenosine
- Cross Reference Drug Bank:
- DB00987 DB00900 DB00898 DB01073 DB00544 DB00441 DB01033 DB00642 DB00811 DB00943
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
integral component of plasma membrane
membrane
plasma membrane
postsynapse
nucleoside transmembrane transporter activity
cellular response to glucose stimulus
cellular response to hypoxia
excitatory postsynaptic potential
lactation
nucleobase-containing compound metabolic process
nucleoside transport
sleep
transmembrane transport
uridine transport - Gene Ontology Biological Process:
- cellular response to glucose stimulus
cellular response to hypoxia
excitatory postsynaptic potential
lactation
nucleobase-containing compound metabolic process
nucleoside transport
sleep
transmembrane transport
uridine transport - Gene Ontology Molecular Function:
- nucleoside transmembrane transporter activity
- Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
integral component of plasma membrane
membrane
plasma membrane
postsynapse - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P49842