Names & Taxonomy

Uniprot ID:
Q99735
Entry Name:
MGST2_HUMAN
Status:
reviewed
Protein Names:
Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Microsomal GST-II)
Gene Names:
MGST2 GST2
Gene Names Primary:
MGST2
Organism:
Homo sapiens (Human)

Structure

Length:
147
Sequence:
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.
Catalytic Activity:
RX + glutathione = HX + R-S-glutathione.
Cross Reference Drug Bank:
DB01008 DB00143
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
enzyme activator activity
glutathione peroxidase activity
glutathione transferase activity
leukotriene-C4 synthase activity
cellular oxidant detoxification
glutathione biosynthetic process
glutathione derivative biosynthetic process
leukotriene biosynthetic process
response to lipopolysaccharide
response to organonitrogen compound
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular oxidant detoxification
glutathione biosynthetic process
glutathione derivative biosynthetic process
leukotriene biosynthetic process
response to lipopolysaccharide
response to organonitrogen compound
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
enzyme activator activity
glutathione peroxidase activity
glutathione transferase activity
leukotriene-C4 synthase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Endoplasmic reticulum
Leukotriene biosynthesis
Membrane
Microsome
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8703034 15815621 15489334 21269460 24275569 25944712