Names & Taxonomy

Uniprot ID:
Q99712
Entry Name:
KCJ15_HUMAN
Status:
reviewed
Protein Names:
ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15)
Gene Names:
KCNJ15 KCNJ14
Gene Names Primary:
KCNJ15
Organism:
Homo sapiens (Human)

Structure

Length:
375
Sequence:
MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQRERELRTLLLQQSNV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.
Intramembrane:
INTRAMEM 114 125 Helical; Pore-forming; Name=H5.

Function

Function:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Cross Reference Drug Bank:
DB01392
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
inward rectifier potassium channel activity
potassium ion import
potassium ion transport
synaptic transmission
Gene Ontology Biological Process:
potassium ion import
potassium ion transport
synaptic transmission
Gene Ontology Molecular Function:
inward rectifier potassium channel activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Complete proteome
Ion channel
Ion transport
Membrane
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
Interacts With:
Q63ZW7

Publication

PubMed ID:
9299242 8995301 10830953 15489334 9647694 16959974