Names & Taxonomy

Uniprot ID:
Q99707
Entry Name:
METH_HUMAN
Status:
reviewed
Protein Names:
Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS)
Gene Names:
MTR
Gene Names Primary:
MTR
Organism:
Homo sapiens (Human)

Structure

Length:
1265
Sequence:
MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
Pathway:
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.
Catalytic Activity:
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
Cofactor:
COFACTOR: Name=methyl(III)cobalamin; Xref=ChEBI:CHEBI:28115; ; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Cross Reference Drug Bank:
DB00115 DB00200 DB00134 DB00116
Gene Ontology Go:
cytoplasm
cytosol
cobalamin binding
methionine synthase activity
S-adenosylmethionine-homocysteine S-methyltransferase activity
zinc ion binding
axon regeneration
cellular nitrogen compound metabolic process
cellular response to nitric oxide
cobalamin metabolic process
methionine biosynthetic process
methylation
nervous system development
pteridine-containing compound metabolic process
response to axon injury
small molecule metabolic process
sulfur amino acid metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
axon regeneration
cellular nitrogen compound metabolic process
cellular response to nitric oxide
cobalamin metabolic process
methionine biosynthetic process
methylation
nervous system development
pteridine-containing compound metabolic process
response to axon injury
small molecule metabolic process
sulfur amino acid metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
cobalamin binding
methionine synthase activity
S-adenosylmethionine-homocysteine S-methyltransferase activity
zinc ion binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
Keywords:
3D-structure
Alternative splicing
Amino-acid biosynthesis
Cobalamin
Cobalt
Complete proteome
Cytoplasm
Disease mutation
Metal-binding
Methionine biosynthesis
Methyltransferase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
S-adenosyl-L-methionine
Transferase
Zinc
Interacts With:
Q9Y4U1

Publication

PubMed ID:
8968737 8968735 9013615 16710414 15489334 21269460 8968736 12375236 15979034