Names & Taxonomy

Uniprot ID:
Q99643
Entry Name:
C560_HUMAN
Status:
reviewed
Protein Names:
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1) (Succinate dehydrogenase complex subunit C) (Succinate-ubiquinone oxidoreductase cytochrome B large subunit) (CYBL)
Gene Names:
SDHC CYB560 SDH3
Gene Names Primary:
SDHC
Organism:
Homo sapiens (Human)

Structure

Length:
169
Sequence:
MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYSWSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFALVFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion inner membrane; Multi-pass membrane protein.

Function

Function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Pathway:
Carbohydrate metabolism; tricarboxylic acid cycle.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB00139
Gene Ontology Go:
integral component of membrane
mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
respiratory chain complex II
electron carrier activity
heme binding
metal ion binding
succinate dehydrogenase activity
aerobic respiration
cellular metabolic process
mitochondrial electron transport, succinate to ubiquinone
oxidation-reduction process
respiratory electron transport chain
small molecule metabolic process
tricarboxylic acid cycle
Gene Ontology Biological Process:
aerobic respiration
cellular metabolic process
mitochondrial electron transport, succinate to ubiquinone
oxidation-reduction process
respiratory electron transport chain
small molecule metabolic process
tricarboxylic acid cycle
Gene Ontology Molecular Function:
electron carrier activity
heme binding
metal ion binding
succinate dehydrogenase activity
Gene Ontology Cellular Component:
integral component of membrane
mitochondrial inner membrane
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
mitochondrion
respiratory chain complex II
Keywords:
Alternative splicing
Complete proteome
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix
Transport
Tricarboxylic acid cycle

Publication

PubMed ID:
9533030 9714607 9851882 14702039 16710414 15489334 11062460 17804857 21269460 25944712