Names & Taxonomy
- Uniprot ID:
- Q99584
- Entry Name:
- S10AD_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein S100-A13 (S100 calcium-binding protein A13)
- Gene Names:
- S100A13
- Gene Names Primary:
- S100A13
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 98
- Sequence:
- MAAEPLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQQLPHLLKDVGSLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Secreted. Note=Secretion is mediated by exposure to stress and requires copper ions.
Function
- Function:
- Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).
- Cross Reference Drug Bank:
- DB01025 DB00768
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
extracellular space
mast cell granule
nucleus
perinuclear region of cytoplasm
calcium ion binding
copper ion binding
fibroblast growth factor binding
lipid binding
protein homodimerization activity
RAGE receptor binding
zinc ion binding
cytokine secretion
interleukin-1 alpha secretion
mast cell degranulation
positive regulation of cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cell shape
response to copper ion
response to electrical stimulus - Gene Ontology Biological Process:
- cytokine secretion
interleukin-1 alpha secretion
mast cell degranulation
positive regulation of cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cell shape
response to copper ion
response to electrical stimulus - Gene Ontology Molecular Function:
- calcium ion binding
copper ion binding
fibroblast growth factor binding
lipid binding
protein homodimerization activity
RAGE receptor binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
extracellular space
mast cell granule
nucleus
perinuclear region of cytoplasm - Keywords:
- 3D-structure
Calcium
Complete proteome
Copper
Cytoplasm
Lipid-binding
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Repeat
Secreted
Transport - Interacts With:
- Q9H8W4