Names & Taxonomy

Uniprot ID:
Q99571
Entry Name:
P2RX4_HUMAN
Status:
reviewed
Protein Names:
P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor)
Gene Names:
P2RX4
Gene Names Primary:
P2RX4
Organism:
Homo sapiens (Human)

Structure

Length:
388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
Cross Reference Drug Bank:
DB09119
Gene Ontology Go:
cell junction
dendritic spine
extracellular exosome
integral component of nuclear inner membrane
integral component of plasma membrane
lysosomal membrane
membrane
neuronal cell body
perinuclear region of cytoplasm
plasma membrane
postsynaptic density
terminal bouton
ATP binding
cadherin binding
copper ion binding
drug binding
extracellular ATP-gated cation channel activity
protein homodimerization activity
purinergic nucleotide receptor activity
receptor binding
zinc ion binding
apoptotic signaling pathway
cellular response to ATP
endothelial cell activation
ion transmembrane transport
membrane depolarization
negative regulation of cardiac muscle hypertrophy
neuronal action potential
positive regulation of calcium ion transport
positive regulation of calcium ion transport into cytosol
positive regulation of calcium-mediated signaling
positive regulation of nitric oxide biosynthetic process
positive regulation of prostaglandin secretion
protein homooligomerization
purinergic nucleotide receptor signaling pathway
regulation of blood pressure
regulation of cardiac muscle contraction
regulation of sodium ion transport
relaxation of cardiac muscle
response to ATP
response to fluid shear stress
sensory perception of pain
signal transduction
tissue homeostasis
transport
Gene Ontology Biological Process:
apoptotic signaling pathway
cellular response to ATP
endothelial cell activation
ion transmembrane transport
membrane depolarization
negative regulation of cardiac muscle hypertrophy
neuronal action potential
positive regulation of calcium ion transport
positive regulation of calcium ion transport into cytosol
positive regulation of calcium-mediated signaling
positive regulation of nitric oxide biosynthetic process
positive regulation of prostaglandin secretion
protein homooligomerization
purinergic nucleotide receptor signaling pathway
regulation of blood pressure
regulation of cardiac muscle contraction
regulation of sodium ion transport
relaxation of cardiac muscle
response to ATP
response to fluid shear stress
sensory perception of pain
signal transduction
tissue homeostasis
transport
Gene Ontology Molecular Function:
ATP binding
cadherin binding
copper ion binding
drug binding
extracellular ATP-gated cation channel activity
protein homodimerization activity
purinergic nucleotide receptor activity
receptor binding
zinc ion binding
Gene Ontology Cellular Component:
cell junction
dendritic spine
extracellular exosome
integral component of nuclear inner membrane
integral component of plasma membrane
lysosomal membrane
membrane
neuronal cell body
perinuclear region of cytoplasm
plasma membrane
postsynaptic density
terminal bouton
Keywords:
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Receptor
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
P26371; Q7Z3S9; Q9NQM4

Publication

PubMed ID:
9016352 16541075 15489334 10515189 19159218