Names & Taxonomy
- Uniprot ID:
- Q99542
- Entry Name:
- MMP19_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18)
- Gene Names:
- MMP19 MMP18 RASI
- Gene Names Primary:
- MMP19
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 508
- Sequence:
- MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
- Catalytic Activity:
- Cleaves aggrecan at the 360-Ser-|-Phe-361 site.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient.
- Active Site:
- ACT_SITE 213 213
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular region
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
zinc ion binding
angiogenesis
cell differentiation
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
luteolysis
ovarian follicle development
ovulation from ovarian follicle
proteolysis
response to cAMP
response to hormone - Gene Ontology Biological Process:
- angiogenesis
cell differentiation
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
luteolysis
ovarian follicle development
ovulation from ovarian follicle
proteolysis
response to cAMP
response to hormone - Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Angiogenesis
Calcium
Collagen degradation
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen