Names & Taxonomy
- Uniprot ID:
- Q99466
- Entry Name:
- NOTC4_HUMAN
- Status:
- reviewed
- Protein Names:
- Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]
- Gene Names:
- NOTCH4 INT3
- Gene Names Primary:
- NOTCH4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2003
- Sequence:
- MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.; Notch 4 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
Function
- Function:
- Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
- Gene Ontology Go:
- cell surface
cytosol
endoplasmic reticulum membrane
extracellular region
Golgi membrane
integral component of plasma membrane
nucleoplasm
nucleus
plasma membrane
calcium ion binding
protein heterodimerization activity
receptor activity
cell differentiation
cell fate determination
embryo development
endothelial cell morphogenesis
gene expression
hemopoiesis
mammary gland development
morphogenesis of a branching structure
negative regulation of cell differentiation
negative regulation of endothelial cell differentiation
Notch receptor processing
Notch signaling pathway
patterning of blood vessels
positive regulation of transcription of Notch receptor target
positive regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cell differentiation
cell fate determination
embryo development
endothelial cell morphogenesis
gene expression
hemopoiesis
mammary gland development
morphogenesis of a branching structure
negative regulation of cell differentiation
negative regulation of endothelial cell differentiation
Notch receptor processing
Notch signaling pathway
patterning of blood vessels
positive regulation of transcription, DNA-templated
positive regulation of transcription of Notch receptor target
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- calcium ion binding
protein heterodimerization activity
receptor activity - Gene Ontology Cellular Component:
- cell surface
cytosol
endoplasmic reticulum membrane
extracellular region
Golgi membrane
integral component of plasma membrane
nucleoplasm
nucleus
plasma membrane - Keywords:
- ANK repeat
Activator
Alternative splicing
Cell membrane
Complete proteome
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Notch signaling pathway
Nucleus
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transcription
Transcription regulation
Transmembrane
Transmembrane helix
Triplet repeat expansion