Names & Taxonomy
- Uniprot ID:
- Q99456
- Entry Name:
- K1C12_HUMAN
- Status:
- reviewed
- Protein Names:
- Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12)
- Gene Names:
- KRT12
- Gene Names Primary:
- KRT12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 494
- Sequence:
- MDLSNNTMSLSVRTPGLSRRLSSQSVIGRPRGMSASSVGSGYGGSAFGFGASCGGGFSAASMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFGGSPGGGSLGILSGNDGGLLSGSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSKYYPLIEDLRNKIISASIGNAQLLLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRVLDELTLTRTDLEMQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDSSKDPTKTRKIKTVVQEMVNGEVVSSQVQEIEELM
- Proteomes:
- UP000005640
Function
- Function:
- May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity).
- Cross Reference Drug Bank:
- DB00400
- Gene Ontology Go:
- extracellular exosome
intermediate filament
structural molecule activity
visual perception - Gene Ontology Biological Process:
- visual perception
- Gene Ontology Molecular Function:
- structural molecule activity
- Gene Ontology Cellular Component:
- extracellular exosome
intermediate filament - Keywords:
- Coiled coil
Complete proteome
Corneal dystrophy
Direct protein sequencing
Disease mutation
Intermediate filament
Keratin
Polymorphism
Reference proteome