Names & Taxonomy
- Uniprot ID:
- Q99435
- Entry Name:
- NELL2_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2)
- Gene Names:
- NELL2 NRP2
- Gene Names Primary:
- NELL2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 816
- Sequence:
- MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).
- Gene Ontology Go:
- cytoplasm
dendrite
extracellular space
membrane
perikaryon
calcium ion binding
heparin binding
neuron cellular homeostasis
protein homotrimerization
regulation of growth - Gene Ontology Biological Process:
- neuron cellular homeostasis
protein homotrimerization
regulation of growth - Gene Ontology Molecular Function:
- calcium ion binding
heparin binding - Gene Ontology Cellular Component:
- cytoplasm
dendrite
extracellular space
membrane
perikaryon - Keywords:
- Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal - Interacts With:
- Q5VTD9