Names & Taxonomy

Uniprot ID:
Q99435
Entry Name:
NELL2_HUMAN
Status:
reviewed
Protein Names:
Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2)
Gene Names:
NELL2 NRP2
Gene Names Primary:
NELL2
Organism:
Homo sapiens (Human)

Structure

Length:
816
Sequence:
MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).
Gene Ontology Go:
cytoplasm
dendrite
extracellular space
membrane
perikaryon
calcium ion binding
heparin binding
neuron cellular homeostasis
protein homotrimerization
regulation of growth
Gene Ontology Biological Process:
neuron cellular homeostasis
protein homotrimerization
regulation of growth
Gene Ontology Molecular Function:
calcium ion binding
heparin binding
Gene Ontology Cellular Component:
cytoplasm
dendrite
extracellular space
membrane
perikaryon
Keywords:
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Interacts With:
Q5VTD9

Publication

PubMed ID:
8975702 14702039 16541075 15489334 15340161