Names & Taxonomy

Uniprot ID:
Q99418
Entry Name:
CYH2_HUMAN
Status:
reviewed
Protein Names:
Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)
Gene Names:
CYTH2 ARNO PSCD2 PSCD2L
Gene Names Primary:
CYTH2
Organism:
Homo sapiens (Human)

Structure

Length:
400
Sequence:
MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth (By similarity).
Gene Ontology Go:
cytoplasm
growth cone
membrane
plasma membrane
ARF guanyl-nucleotide exchange factor activity
inositol 1,4,5 trisphosphate binding
lipid binding
actin cytoskeleton organization
endocytosis
positive regulation of GTPase activity
regulation of ARF protein signal transduction
Gene Ontology Biological Process:
actin cytoskeleton organization
endocytosis
positive regulation of GTPase activity
regulation of ARF protein signal transduction
Gene Ontology Molecular Function:
ARF guanyl-nucleotide exchange factor activity
inositol 1,4,5 trisphosphate binding
lipid binding
Gene Ontology Cellular Component:
cytoplasm
growth cone
membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Guanine-nucleotide releasing factor
Lipid-binding
Membrane
Reference proteome
Interacts With:
P29274; P84077; Q9Y487; Q96HB5-4; P00533

Publication

PubMed ID:
8945478 9417041 14702039 15489334 17623778 17398095 25326380 9476900 9510256 14654833