Names & Taxonomy
- Uniprot ID:
- Q99418
- Entry Name:
- CYH2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)
- Gene Names:
- CYTH2 ARNO PSCD2 PSCD2L
- Gene Names Primary:
- CYTH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 400
- Sequence:
- MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth (By similarity).
- Gene Ontology Go:
- cytoplasm
growth cone
membrane
plasma membrane
ARF guanyl-nucleotide exchange factor activity
inositol 1,4,5 trisphosphate binding
lipid binding
actin cytoskeleton organization
endocytosis
positive regulation of GTPase activity
regulation of ARF protein signal transduction - Gene Ontology Biological Process:
- actin cytoskeleton organization
endocytosis
positive regulation of GTPase activity
regulation of ARF protein signal transduction - Gene Ontology Molecular Function:
- ARF guanyl-nucleotide exchange factor activity
inositol 1,4,5 trisphosphate binding
lipid binding - Gene Ontology Cellular Component:
- cytoplasm
growth cone
membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Guanine-nucleotide releasing factor
Lipid-binding
Membrane
Reference proteome - Interacts With:
- P29274; P84077; Q9Y487; Q96HB5-4; P00533