Names & Taxonomy

Uniprot ID:
Q96RD7
Entry Name:
PANX1_HUMAN
Status:
reviewed
Protein Names:
Pannexin-1
Gene Names:
PANX1 MRS1 UNQ2529/PRO6028
Gene Names Orf:
UNQ2529/PRO6028
Gene Names Primary:
PANX1
Organism:
Homo sapiens (Human)

Structure

Length:
426
Sequence:
MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.
Cross Reference Drug Bank:
DB01032
Gene Ontology Go:
bleb
endoplasmic reticulum
endoplasmic reticulum membrane
gap junction
integral component of membrane
membrane
plasma membrane
protein complex
calcium channel activity
gap junction hemi-channel activity
leak channel activity
receptor binding
calcium ion transport
cation transport
cell-cell signaling
innate immune response
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
protein hexamerization
response to ATP
response to ischemia
synaptic transmission
Gene Ontology Biological Process:
calcium ion transport
cation transport
cell-cell signaling
innate immune response
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
protein hexamerization
response to ATP
response to ischemia
synaptic transmission
Gene Ontology Molecular Function:
calcium channel activity
gap junction hemi-channel activity
leak channel activity
receptor binding
Gene Ontology Cellular Component:
bleb
endoplasmic reticulum
endoplasmic reticulum membrane
gap junction
integral component of membrane
membrane
plasma membrane
protein complex
Keywords:
Alternative splicing
Calcium
Calcium channel
Calcium transport
Cell junction
Cell membrane
Complete proteome
Endoplasmic reticulum
Gap junction
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Reference proteome
S-nitrosylation
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
15028292 12975309 16303743 16554811 15489334 16908669 17715132 20829356