Names & Taxonomy
- Uniprot ID:
- Q96RD7
- Entry Name:
- PANX1_HUMAN
- Status:
- reviewed
- Protein Names:
- Pannexin-1
- Gene Names:
- PANX1 MRS1 UNQ2529/PRO6028
- Gene Names Orf:
- UNQ2529/PRO6028
- Gene Names Primary:
- PANX1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 426
- Sequence:
- MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.
- Cross Reference Drug Bank:
- DB01032
- Gene Ontology Go:
- bleb
endoplasmic reticulum
endoplasmic reticulum membrane
gap junction
integral component of membrane
membrane
plasma membrane
protein complex
calcium channel activity
gap junction hemi-channel activity
leak channel activity
receptor binding
calcium ion transport
cation transport
cell-cell signaling
innate immune response
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
protein hexamerization
response to ATP
response to ischemia
synaptic transmission - Gene Ontology Biological Process:
- calcium ion transport
cation transport
cell-cell signaling
innate immune response
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
protein hexamerization
response to ATP
response to ischemia
synaptic transmission - Gene Ontology Molecular Function:
- calcium channel activity
gap junction hemi-channel activity
leak channel activity
receptor binding - Gene Ontology Cellular Component:
- bleb
endoplasmic reticulum
endoplasmic reticulum membrane
gap junction
integral component of membrane
membrane
plasma membrane
protein complex - Keywords:
- Alternative splicing
Calcium
Calcium channel
Calcium transport
Cell junction
Cell membrane
Complete proteome
Endoplasmic reticulum
Gap junction
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Reference proteome
S-nitrosylation
Transmembrane
Transmembrane helix
Transport