Names & Taxonomy
- Uniprot ID:
- Q96QD8
- Entry Name:
- S38A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-coupled neutral amino acid transporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)
- Gene Names:
- SLC38A2 ATA2 KIAA1382 SAT2 SNAT2
- Gene Names Primary:
- SLC38A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 506
- Sequence:
- MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0);
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by N-methyl-D-glucamine and probably choline.
- Gene Ontology Go:
- axon
brush border
dendrite
integral component of plasma membrane
neuronal cell body
plasma membrane
presynapse
sarcolemma
amino acid transmembrane transporter activity
symporter activity
alanine transport
amino acid transmembrane transport
amino acid transport
cellular response to amino acid starvation
cellular response to mechanical stimulus
cerebral cortex development
female pregnancy
glutamate secretion
glycine betaine transport
ion transport
neurotransmitter secretion
sodium ion transport
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- alanine transport
amino acid transmembrane transport
amino acid transport
cellular response to amino acid starvation
cellular response to mechanical stimulus
cerebral cortex development
female pregnancy
glutamate secretion
glycine betaine transport
ion transport
neurotransmitter secretion
sodium ion transport
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- amino acid transmembrane transporter activity
symporter activity - Gene Ontology Cellular Component:
- axon
brush border
dendrite
integral component of plasma membrane
neuronal cell body
plasma membrane
presynapse
sarcolemma - Keywords:
- Alternative splicing
Amino-acid transport
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport
Ubl conjugation - Interacts With:
- Q99942