Names & Taxonomy
- Uniprot ID:
- Q96Q40
- Entry Name:
- CDK15_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2)
- Gene Names:
- CDK15 ALS2CR7 PFTK2
- Gene Names Primary:
- CDK15
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 435
- Sequence:
- MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLASYQKGHHPAQFSKCW
- Proteomes:
- UP000005640
Function
- Function:
- Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 224 224 Proton acceptor.
- Cross Reference Drug Bank:
- DB00171
- Gene Ontology Go:
- ATP binding
cyclin-dependent protein serine/threonine kinase activity
metal ion binding
protein serine/threonine kinase activity - Gene Ontology Molecular Function:
- ATP binding
cyclin-dependent protein serine/threonine kinase activity
metal ion binding
protein serine/threonine kinase activity - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase - Interacts With:
- Q16543; Q13451; P08238