Names & Taxonomy

Uniprot ID:
Q96Q40
Entry Name:
CDK15_HUMAN
Status:
reviewed
Protein Names:
Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2)
Gene Names:
CDK15 ALS2CR7 PFTK2
Gene Names Primary:
CDK15
Organism:
Homo sapiens (Human)

Structure

Length:
435
Sequence:
MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLASYQKGHHPAQFSKCW
Proteomes:
UP000005640

Function

Function:
Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:
ACT_SITE 224 224 Proton acceptor.
Cross Reference Drug Bank:
DB00171
Gene Ontology Go:
ATP binding
cyclin-dependent protein serine/threonine kinase activity
metal ion binding
protein serine/threonine kinase activity
Gene Ontology Molecular Function:
ATP binding
cyclin-dependent protein serine/threonine kinase activity
metal ion binding
protein serine/threonine kinase activity
Keywords:
ATP-binding
Alternative splicing
Complete proteome
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Interacts With:
Q16543; Q13451; P08238

Publication

PubMed ID:
11586298 14702039 15815621 15489334 12471243 17344846 24866247