Names & Taxonomy
- Uniprot ID:
- Q96PR1
- Entry Name:
- KCNC2_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily C member 2 (Shaw-like potassium channel) (Voltage-gated potassium channel Kv3.2)
- Gene Names:
- KCNC2
- Gene Names Primary:
- KCNC2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 638
- Sequence:
- MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity).
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: Note=Homotetrameric channels expressed in xenopus oocytes or in mammalian non-neuronal cells display delayed-rectifier voltage-dependent potassium currents, that are rapidly activated during membrane depolarization, i.e within a risetime of a few msec. After that, inactivates very slowly, i.e within about >800 msec. Their activation requires a threshold potential at about -10 mV, with a midpoint activation at about 12.1 mV and a steepness parameter of about 8.4 mV. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, the presence or absence of ancillary subunits and post-translational modifications.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by Stichodactyla helianthus peptide ShK (PubMed:15709110). Inhibited by millimolar levels of tetraethylammonium (TEA). Contrary to other channels, inhibited only by millimolar levels of 4-aminopyridine (4-AP) (By similarity).
- Cross Reference Drug Bank:
- DB06637
- Gene Ontology Go:
- apical plasma membrane
axolemma
axon
basolateral plasma membrane
cell junction
dendrite
integral component of membrane
integral component of plasma membrane
intracellular
membrane
neuronal cell body membrane
perikaryon
plasma membrane
postsynaptic membrane
presynaptic membrane
synapse
terminal bouton
vesicle
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
voltage-gated potassium channel activity
cellular response to ammonium ion
cellular response to nitric oxide
cellular response to toxic substance
energy reserve metabolic process
globus pallidus development
nitric oxide-cGMP-mediated signaling pathway
positive regulation of potassium ion transmembrane transport
potassium ion transmembrane transport
protein heterooligomerization
protein homooligomerization
regulation of insulin secretion
response to amine
response to ethanol
response to light intensity
response to magnesium ion
response to nerve growth factor
response to organic cyclic compound
small molecule metabolic process
synaptic transmission - Gene Ontology Biological Process:
- cellular response to ammonium ion
cellular response to nitric oxide
cellular response to toxic substance
energy reserve metabolic process
globus pallidus development
nitric oxide-cGMP-mediated signaling pathway
positive regulation of potassium ion transmembrane transport
potassium ion transmembrane transport
protein heterooligomerization
protein homooligomerization
regulation of insulin secretion
response to amine
response to ethanol
response to light intensity
response to magnesium ion
response to nerve growth factor
response to organic cyclic compound
small molecule metabolic process
synaptic transmission - Gene Ontology Molecular Function:
- delayed rectifier potassium channel activity
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- apical plasma membrane
axolemma
axon
basolateral plasma membrane
cell junction
dendrite
integral component of membrane
integral component of plasma membrane
intracellular
membrane
neuronal cell body membrane
perikaryon
plasma membrane
postsynaptic membrane
presynaptic membrane
synapse
terminal bouton
vesicle
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Postsynaptic cell membrane
Potassium
Potassium channel
Potassium transport
Reference proteome
Synapse
Synaptosome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel