Names & Taxonomy
- Uniprot ID:
- Q96NT5
- Entry Name:
- PCFT_HUMAN
- Status:
- reviewed
- Protein Names:
- Proton-coupled folate transporter (G21) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
- Gene Names:
- SLC46A1 HCP1 PCFT
- Gene Names Primary:
- SLC46A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 459
- Sequence:
- MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane; Multi-pass membrane protein. Cytoplasm
Function
- Function:
- Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.3 uM for folic acid (at pH 5.5)
- Cross Reference Drug Bank:
- DB00158 DB00563 DB00795
- Gene Ontology Go:
- apical plasma membrane
brush border membrane
cell surface
cytoplasm
integral component of membrane
plasma membrane
folic acid binding
folic acid transporter activity
hydrogen ion transmembrane transporter activity
methotrexate transporter activity
cellular iron ion homeostasis
folic acid import into cell
folic acid metabolic process
folic acid transport
heme transport
hydrogen ion transmembrane transport
intestinal folate absorption
methotrexate transport
small molecule metabolic process
transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- cellular iron ion homeostasis
folic acid import into cell
folic acid metabolic process
folic acid transport
heme transport
hydrogen ion transmembrane transport
intestinal folate absorption
methotrexate transport
small molecule metabolic process
transmembrane transport
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- folic acid binding
folic acid transporter activity
hydrogen ion transmembrane transporter activity
methotrexate transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
brush border membrane
cell surface
cytoplasm
integral component of membrane
plasma membrane - Keywords:
- Acetylation
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Disease mutation
Folate-binding
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport