Names & Taxonomy
- Uniprot ID:
- Q96NR8
- Entry Name:
- RDH12_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2)
- Gene Names:
- RDH12 SDR7C2
- Gene Names Primary:
- RDH12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 316
- Sequence:
- MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE
- Proteomes:
- UP000005640
Function
- Function:
- Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments.
- Active Site:
- ACT_SITE 200 200 Proton acceptor.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- intracellular
photoreceptor inner segment membrane
retinol dehydrogenase activity
photoreceptor cell maintenance
phototransduction, visible light
retinoid metabolic process
retinol metabolic process
visual perception - Gene Ontology Biological Process:
- photoreceptor cell maintenance
phototransduction, visible light
retinoid metabolic process
retinol metabolic process
visual perception - Gene Ontology Molecular Function:
- retinol dehydrogenase activity
- Gene Ontology Cellular Component:
- intracellular
photoreceptor inner segment membrane - Keywords:
- Complete proteome
Disease mutation
Leber congenital amaurosis
NADP
Oxidoreductase
Polymorphism
Reference proteome
Retinitis pigmentosa
Sensory transduction
Vision - Interacts With:
- Q93062; P0CG48