Names & Taxonomy
- Uniprot ID:
- Q96MA6
- Entry Name:
- KAD8_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylate kinase 8 (AK 8) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8)
- Gene Names:
- AK8 C9orf98
- Gene Names Primary:
- AK8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 479
- Sequence:
- MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
- Catalytic Activity:
- ATP + AMP = 2 ADP.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=4.1 uM for AMP
- Gene Ontology Go:
- axoneme
cytosol
sperm flagellum
adenylate kinase activity
ATP binding
cytidylate kinase activity
nucleoside diphosphate kinase activity
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
small molecule metabolic process
ventricular system development - Gene Ontology Biological Process:
- nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
small molecule metabolic process
ventricular system development - Gene Ontology Molecular Function:
- adenylate kinase activity
ATP binding
cytidylate kinase activity
nucleoside diphosphate kinase activity - Gene Ontology Cellular Component:
- axoneme
cytosol
sperm flagellum - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q96Q83; A1A4H1; Q96CS2; P57077-4; P33993; Q9NPA3; Q14498; Q14498-3; Q9H832; Q96NC0