Names & Taxonomy

Uniprot ID:
Q96MA6
Entry Name:
KAD8_HUMAN
Status:
reviewed
Protein Names:
Adenylate kinase 8 (AK 8) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8)
Gene Names:
AK8 C9orf98
Gene Names Primary:
AK8
Organism:
Homo sapiens (Human)

Structure

Length:
479
Sequence:
MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytosol

Function

Function:
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
Catalytic Activity:
ATP + AMP = 2 ADP.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=4.1 uM for AMP
Gene Ontology Go:
axoneme
cytosol
sperm flagellum
adenylate kinase activity
ATP binding
cytidylate kinase activity
nucleoside diphosphate kinase activity
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
small molecule metabolic process
ventricular system development
Gene Ontology Biological Process:
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
small molecule metabolic process
ventricular system development
Gene Ontology Molecular Function:
adenylate kinase activity
ATP binding
cytidylate kinase activity
nucleoside diphosphate kinase activity
Gene Ontology Cellular Component:
axoneme
cytosol
sperm flagellum
Keywords:
ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Polymorphism
Reference proteome
Transferase
Interacts With:
Q96Q83; A1A4H1; Q96CS2; P57077-4; P33993; Q9NPA3; Q14498; Q14498-3; Q9H832; Q96NC0

Publication

PubMed ID:
14702039 15164053 15489334 21080915 23416111