Names & Taxonomy

Uniprot ID:
Q96LB9
Entry Name:
PGRP3_HUMAN
Status:
reviewed
Protein Names:
Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha)
Gene Names:
PGLYRP3 PGRPIA
Gene Names Primary:
PGLYRP3
Organism:
Homo sapiens (Human)

Structure

Length:
341
Sequence:
MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQQQSVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAFFGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPNIIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Gene Ontology Go:
extracellular region
intracellular
membrane
N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
peptidoglycan receptor activity
zinc ion binding
defense response to Gram-positive bacterium
detection of bacterium
growth of symbiont in host
innate immune response
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
pattern recognition receptor signaling pathway
peptidoglycan catabolic process
Gene Ontology Biological Process:
defense response to Gram-positive bacterium
detection of bacterium
growth of symbiont in host
innate immune response
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
pattern recognition receptor signaling pathway
peptidoglycan catabolic process
Gene Ontology Molecular Function:
N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
peptidoglycan receptor activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular region
intracellular
membrane
Keywords:
3D-structure
Antibiotic
Antimicrobial
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Innate immunity
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
11461926 16710414 15489334 16354652 15140887 15572450 16641493