Names & Taxonomy
- Uniprot ID:
- Q96LB9
- Entry Name:
- PGRP3_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha)
- Gene Names:
- PGLYRP3 PGRPIA
- Gene Names Primary:
- PGLYRP3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 341
- Sequence:
- MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQQQSVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAFFGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPNIIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
- Gene Ontology Go:
- extracellular region
intracellular
membrane
N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
peptidoglycan receptor activity
zinc ion binding
defense response to Gram-positive bacterium
detection of bacterium
growth of symbiont in host
innate immune response
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
pattern recognition receptor signaling pathway
peptidoglycan catabolic process - Gene Ontology Biological Process:
- defense response to Gram-positive bacterium
detection of bacterium
growth of symbiont in host
innate immune response
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
pattern recognition receptor signaling pathway
peptidoglycan catabolic process - Gene Ontology Molecular Function:
- N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
peptidoglycan receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
intracellular
membrane - Keywords:
- 3D-structure
Antibiotic
Antimicrobial
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Innate immunity
Polymorphism
Reference proteome
Secreted
Signal