Names & Taxonomy
- Uniprot ID:
- Q96GW9
- Entry Name:
- SYMM_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)
- Gene Names:
- MARS2
- Gene Names Primary:
- MARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 593
- Sequence:
- MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Catalytic Activity:
- ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=18 uM for Met
- Cross Reference Drug Bank:
- DB00134
- Gene Ontology Go:
- mitochondrial matrix
ATP binding
methionine-tRNA ligase activity
gene expression
methionyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
methionyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
methionine-tRNA ligase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
- Keywords:
- ATP-binding
Aminoacyl-tRNA synthetase
Complete proteome
Deafness
Disease mutation
Ligase
Mitochondrion
Neurodegeneration
Nucleotide-binding
Protein biosynthesis
Reference proteome
Transit peptide