Names & Taxonomy
- Uniprot ID:
- Q96CD2
- Entry Name:
- COAC_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC)
- Gene Names:
- PPCDC COAC MDS018 UNQ9365/PRO34154
- Gene Names Orf:
- MDS018 UNQ9365/PRO34154
- Gene Names Primary:
- PPCDC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 204
- Sequence:
- MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLLTCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS
- Proteomes:
- UP000005640
Function
- Function:
- Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
- Pathway:
- Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.
- Catalytic Activity:
- N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO(2).
- Cofactor:
- COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; ; Note=Binds 1 FMN per subunit.;
- Active Site:
- ACT_SITE 173 173 Proton donor.
- Gene Ontology Go:
- cytosol
phosphopantothenoylcysteine decarboxylase activity
coenzyme A biosynthetic process
coenzyme biosynthetic process
pantothenate metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- coenzyme A biosynthetic process
coenzyme biosynthetic process
pantothenate metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- phosphopantothenoylcysteine decarboxylase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Coenzyme A biosynthesis
Complete proteome
Decarboxylase
FMN
Flavoprotein
Lyase
Polymorphism
Reference proteome - Interacts With:
- Q6PIV2; Q13427; Q8N9Q2; Q99757; Q96HA8; Q9UNY5