Names & Taxonomy
- Uniprot ID:
- Q969S8
- Entry Name:
- HDA10_HUMAN
- Status:
- reviewed
- Protein Names:
- Histone deacetylase 10 (HD10) (EC 3.5.1.98)
- Gene Names:
- HDAC10
- Gene Names Primary:
- HDAC10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 669
- Sequence:
- MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Note=Excluded from the nucleoli.
Function
- Function:
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
- Catalytic Activity:
- Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
- Active Site:
- ACT_SITE 135 135
- Cross Reference Drug Bank:
- DB06603
- Gene Ontology Go:
- cytoplasm
histone deacetylase complex
nucleoplasm
nucleus
enzyme binding
histone deacetylase activity
histone deacetylase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
chromatin modification
chromatin organization
histone deacetylation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
Notch signaling pathway
oligodendrocyte development
protein deacetylation
regulation of transcription, DNA-templated
transcription, DNA-templated - Gene Ontology Biological Process:
- chromatin modification
chromatin organization
histone deacetylation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
oligodendrocyte development
protein deacetylation
regulation of transcription, DNA-templated
transcription, DNA-templated - Gene Ontology Molecular Function:
- enzyme binding
histone deacetylase activity
histone deacetylase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity - Gene Ontology Cellular Component:
- cytoplasm
histone deacetylase complex
nucleoplasm
nucleus - Keywords:
- Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Hydrolase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation