Names & Taxonomy

Uniprot ID:
Q969N4
Entry Name:
TAAR8_HUMAN
Status:
reviewed
Protein Names:
Trace amine-associated receptor 8 (TaR-8) (Trace amine receptor 8) (G-protein coupled receptor 102) (Trace amine receptor 5) (TaR-5)
Gene Names:
TAAR8 GPR102 TA5 TAR5 TRAR5
Gene Names Primary:
TAAR8
Organism:
Homo sapiens (Human)

Structure

Length:
342
Sequence:
MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
Gene Ontology Go:
integral component of membrane
plasma membrane
G-protein coupled receptor activity
trace-amine receptor activity
G-protein coupled receptor signaling pathway
Gene Ontology Biological Process:
G-protein coupled receptor signaling pathway
Gene Ontology Molecular Function:
G-protein coupled receptor activity
trace-amine receptor activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11459929 11574155 14574404 15489334 21885028