Names & Taxonomy

Uniprot ID:
Q969I6
Entry Name:
S38A4_HUMAN
Status:
reviewed
Protein Names:
Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3)
Gene Names:
SLC38A4 ATA3 NAT3 SNAT4
Gene Names Primary:
SLC38A4
Organism:
Homo sapiens (Human)

Structure

Length:
547
Sequence:
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGKKKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDENQAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYDPPNSKHH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
amino acid transmembrane transporter activity
symporter activity
amino acid transmembrane transport
amino acid transport
ion transport
sodium ion transport
transmembrane transport
Gene Ontology Biological Process:
amino acid transmembrane transport
amino acid transport
ion transport
sodium ion transport
transmembrane transport
Gene Ontology Molecular Function:
amino acid transmembrane transporter activity
symporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Amino-acid transport
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
11342143 11414754 14702039 15489334 12845534 16148032 21917917