Names & Taxonomy
- Uniprot ID:
- Q93088
- Entry Name:
- BHMT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5)
- Gene Names:
- BHMT
- Gene Names Primary:
- BHMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 406
- Sequence:
- MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
- Pathway:
- Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.
- Catalytic Activity:
- Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 1 zinc ion per subunit.;
- Cross Reference Drug Bank:
- DB00134
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
betaine-homocysteine S-methyltransferase activity
S-adenosylmethionine-homocysteine S-methyltransferase activity
zinc ion binding
amino-acid betaine catabolic process
amino-acid betaine metabolic process
cellular nitrogen compound metabolic process
L-methionine salvage
protein methylation
regulation of homocysteine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Biological Process:
- amino-acid betaine catabolic process
amino-acid betaine metabolic process
cellular nitrogen compound metabolic process
L-methionine salvage
protein methylation
regulation of homocysteine metabolic process
small molecule metabolic process
sulfur amino acid metabolic process - Gene Ontology Molecular Function:
- betaine-homocysteine S-methyltransferase activity
S-adenosylmethionine-homocysteine S-methyltransferase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Metal-binding
Methyltransferase
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Zinc