Names & Taxonomy
- Uniprot ID:
- Q93084
- Entry Name:
- AT2A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 3.6.3.8) (Calcium pump 3)
- Gene Names:
- ATP2A3
- Gene Names Primary:
- ATP2A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1043
- Sequence:
- MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMHACLYPGLLRTVSQAWSRQPLTTSWTPDHTGRNEPEVSAGNRVESPVCTSD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus membrane
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).
- Active Site:
- ACT_SITE 351 351 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
nuclear membrane
platelet dense tubular network membrane
sarcoplasmic reticulum
sarcoplasmic reticulum membrane
ATP binding
calcium-transporting ATPase activity
metal ion binding
blood coagulation
calcium ion transport
cardiac conduction
cellular calcium ion homeostasis
ion transmembrane transport
regulation of cardiac conduction
transmembrane transport
transport - Gene Ontology Biological Process:
- blood coagulation
calcium ion transport
cardiac conduction
cellular calcium ion homeostasis
ion transmembrane transport
regulation of cardiac conduction
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATP binding
calcium-transporting ATPase activity
metal ion binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
nuclear membrane
platelet dense tubular network membrane
sarcoplasmic reticulum
sarcoplasmic reticulum membrane - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Calcium
Calcium transport
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Sarcoplasmic reticulum
Transmembrane
Transmembrane helix
Transport