Names & Taxonomy

Uniprot ID:
Q92959
Entry Name:
SO2A1_HUMAN
Status:
reviewed
Protein Names:
Solute carrier organic anion transporter family member 2A1 (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2)
Gene Names:
SLCO2A1 OATP2A1 SLC21A2
Gene Names Primary:
SLCO2A1
Organism:
Homo sapiens (Human)

Structure

Length:
643
Sequence:
MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.
Cross Reference Drug Bank:
DB00770 DB01160 DB00917 DB00695 DB01088 DB04398 DB01174 DB00119
Gene Ontology Go:
integral component of plasma membrane
membrane
plasma membrane
lipid transporter activity
prostaglandin transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
lipid transport
sodium-independent organic anion transport
transmembrane transport
Gene Ontology Biological Process:
lipid transport
sodium-independent organic anion transport
transmembrane transport
Gene Ontology Molecular Function:
lipid transporter activity
prostaglandin transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
membrane
plasma membrane
Keywords:
3D-structure
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
P62993

Publication

PubMed ID:
8787677 9618293 15489334 22331663 22814378 22197487 22553128 22696055