Names & Taxonomy
- Uniprot ID:
- Q92911
- Entry Name:
- SC5A5_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5)
- Gene Names:
- SLC5A5 NIS
- Gene Names Primary:
- SLC5A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 643
- Sequence:
- MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEYLEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTAVGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRSRYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCGIVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPCVGHDGGRDQQETNL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Mediates iodide uptake in the thyroid gland.
- Gene Ontology Go:
- extracellular exosome
extracellular vesicle
integral component of membrane
nucleus
plasma membrane
iodide transmembrane transporter activity
sodium:iodide symporter activity
cellular nitrogen compound metabolic process
cellular response to cAMP
cellular response to gonadotropin stimulus
iodide transport
ion transport
small molecule metabolic process
thyroid hormone generation
transmembrane transport
transport - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cellular response to cAMP
cellular response to gonadotropin stimulus
iodide transport
ion transport
small molecule metabolic process
thyroid hormone generation
transmembrane transport
transport - Gene Ontology Molecular Function:
- iodide transmembrane transporter activity
sodium:iodide symporter activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular vesicle
integral component of membrane
nucleus
plasma membrane - Keywords:
- Complete proteome
Congenital hypothyroidism
Disease mutation
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport