Names & Taxonomy

Uniprot ID:
Q92887
Entry Name:
MRP2_HUMAN
Status:
reviewed
Protein Names:
Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2)
Gene Names:
ABCC2 CMOAT CMOAT1 CMRP MRP2
Gene Names Primary:
ABCC2
Organism:
Homo sapiens (Human)

Structure

Length:
1545
Sequence:
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane

Function

Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Cross Reference Drug Bank:
DB00171 DB00345 DB01169 DB01076 DB09060 DB08907 DB00564 DB00958 DB02659 DB00515 DB00257 DB00286 DB00091 DB00694 DB01234 DB01248 DB00997 DB09272 DB00876 DB00977 DB00773 DB00973 DB00695 DB02703 DB08884 DB00143 DB01016 DB00224 DB00328 DB00762 DB00602 DB00709 DB00650 DB01202 DB00978 DB00227 DB00563 DB00688 DB01115 DB00957 DB01165 DB00275 DB00526 DB01229 DB01174 DB00252 DB08860 DB01411 DB00175 DB01032 DB00908 DB00206 DB01045 DB00503 DB01232 DB00641 DB00398 DB01208 DB00421 DB00795 DB01138 DB01268 DB00675 DB00966 DB00300 DB00116 DB01586 DB00067 DB00661 DB00570 DB00541
Gene Ontology Go:
apical plasma membrane
cell surface
integral component of plasma membrane
intercellular canaliculus
plasma membrane
ATP binding
ATPase activity, coupled to transmembrane movement of substances
organic anion transmembrane transporter activity
cellular chloride ion homeostasis
drug transmembrane transport
prostaglandin transport
response to arsenic-containing substance
response to estrogen
response to heat
response to methotrexate
response to oxidative stress
thyroid hormone transport
transmembrane transport
transport
Gene Ontology Biological Process:
cellular chloride ion homeostasis
drug transmembrane transport
prostaglandin transport
response to arsenic-containing substance
response to estrogen
response to heat
response to methotrexate
response to oxidative stress
thyroid hormone transport
transmembrane transport
transport
Gene Ontology Molecular Function:
ATPase activity, coupled to transmembrane movement of substances
ATP binding
organic anion transmembrane transporter activity
Gene Ontology Cellular Component:
apical plasma membrane
cell surface
integral component of plasma membrane
intercellular canaliculus
plasma membrane
Keywords:
ATP-binding
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Interacts With:
P19838

Publication

PubMed ID:
8797578 8662992 10464142 15164054 15489334 11076395 11500505 18691976 18669648 20068231 21269460 24275569 9425227 10053008 11093739 11477083 11266082 22290738 25336012