Names & Taxonomy
- Uniprot ID:
- Q92832
- Entry Name:
- NELL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein kinase C-binding protein NELL1 (NEL-like protein 1) (Nel-related protein 1)
- Gene Names:
- NELL1 NRP1
- Gene Names Primary:
- NELL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 810
- Sequence:
- MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQNN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.
- Gene Ontology Go:
- cytoplasm
extracellular region
nuclear envelope
perinuclear region of cytoplasm
calcium ion binding
cell differentiation
negative regulation of cyclin catabolic process
negative regulation of osteoblast proliferation
nervous system development
positive regulation of bone mineralization
positive regulation of osteoblast differentiation
regulation of gene expression - Gene Ontology Biological Process:
- cell differentiation
negative regulation of cyclin catabolic process
negative regulation of osteoblast proliferation
nervous system development
positive regulation of bone mineralization
positive regulation of osteoblast differentiation
regulation of gene expression - Gene Ontology Molecular Function:
- calcium ion binding
- Gene Ontology Cellular Component:
- cytoplasm
extracellular region
nuclear envelope
perinuclear region of cytoplasm - Keywords:
- Alternative splicing
Calcium
Complete proteome
Cytoplasm
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Nucleus
Polymorphism
Reference proteome
Repeat
Secreted
Signal - Interacts With:
- Q6UW56