Names & Taxonomy
- Uniprot ID:
- Q92820
- Entry Name:
- GGH_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)
- Gene Names:
- GGH
- Gene Names Primary:
- GGH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 318
- Sequence:
- MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space
Function
- Function:
- Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
- Catalytic Activity:
- Hydrolysis of a gamma-glutamyl bond.
- Active Site:
- ACT_SITE 134 134 Nucleophile.; ACT_SITE 244 244 Proton donor.
- Cross Reference Drug Bank:
- DB00158 DB00563
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular space
lysosome
melanosome
nucleus
vacuole
exopeptidase activity
gamma-glutamyl-peptidase activity
omega peptidase activity
glutamine metabolic process
proteolysis
response to drug
response to ethanol
response to insulin
response to zinc ion
tetrahydrofolylpolyglutamate metabolic process - Gene Ontology Biological Process:
- glutamine metabolic process
proteolysis
response to drug
response to ethanol
response to insulin
response to zinc ion
tetrahydrofolylpolyglutamate metabolic process - Gene Ontology Molecular Function:
- exopeptidase activity
gamma-glutamyl-peptidase activity
omega peptidase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular space
lysosome
melanosome
nucleus
vacuole - Keywords:
- 3D-structure
Complete proteome
Glycoprotein
Hydrolase
Lysosome
Polymorphism
Reference proteome
Secreted
Signal