Names & Taxonomy

Uniprot ID:
Q92820
Entry Name:
GGH_HUMAN
Status:
reviewed
Protein Names:
Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)
Gene Names:
GGH
Gene Names Primary:
GGH
Organism:
Homo sapiens (Human)

Structure

Length:
318
Sequence:
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space

Function

Function:
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Catalytic Activity:
Hydrolysis of a gamma-glutamyl bond.
Active Site:
ACT_SITE 134 134 Nucleophile.; ACT_SITE 244 244 Proton donor.
Cross Reference Drug Bank:
DB00158 DB00563
Gene Ontology Go:
cytosol
extracellular exosome
extracellular space
lysosome
melanosome
nucleus
vacuole
exopeptidase activity
gamma-glutamyl-peptidase activity
omega peptidase activity
glutamine metabolic process
proteolysis
response to drug
response to ethanol
response to insulin
response to zinc ion
tetrahydrofolylpolyglutamate metabolic process
Gene Ontology Biological Process:
glutamine metabolic process
proteolysis
response to drug
response to ethanol
response to insulin
response to zinc ion
tetrahydrofolylpolyglutamate metabolic process
Gene Ontology Molecular Function:
exopeptidase activity
gamma-glutamyl-peptidase activity
omega peptidase activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
extracellular space
lysosome
melanosome
nucleus
vacuole
Keywords:
3D-structure
Complete proteome
Glycoprotein
Hydrolase
Lysosome
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
8816764 10570974 15489334 10527932 11005824 12643545 16945597 17081065 21269460 24275569 11953431