Names & Taxonomy

Uniprot ID:
Q92819
Entry Name:
HYAS2_HUMAN
Status:
reviewed
Protein Names:
Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2)
Gene Names:
HAS2
Gene Names Primary:
HAS2
Organism:
Homo sapiens (Human)

Structure

Length:
552
Sequence:
MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).
Pathway:
Glycan biosynthesis; hyaluronan biosynthesis.
Catalytic Activity:
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).; UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
hyaluronan synthase activity
atrioventricular canal development
bone morphogenesis
cell adhesion
cellular response to fluid shear stress
cellular response to interleukin-1
cellular response to platelet-derived growth factor stimulus
cellular response to tumor necrosis factor
endocardial cushion to mesenchymal transition
estrous cycle
extracellular matrix assembly
extracellular polysaccharide biosynthetic process
hyaluronan biosynthetic process
kidney development
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of hyaluronan biosynthetic process
positive regulation of keratinocyte migration
positive regulation of keratinocyte proliferation
positive regulation of monocyte aggregation
positive regulation of smooth muscle cell migration
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of urine volume
renal water absorption
vasculogenesis
Gene Ontology Biological Process:
atrioventricular canal development
bone morphogenesis
cell adhesion
cellular response to fluid shear stress
cellular response to interleukin-1
cellular response to platelet-derived growth factor stimulus
cellular response to tumor necrosis factor
endocardial cushion to mesenchymal transition
estrous cycle
extracellular matrix assembly
extracellular polysaccharide biosynthetic process
hyaluronan biosynthetic process
kidney development
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of hyaluronan biosynthetic process
positive regulation of keratinocyte migration
positive regulation of keratinocyte proliferation
positive regulation of monocyte aggregation
positive regulation of smooth muscle cell migration
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of urine volume
renal water absorption
vasculogenesis
Gene Ontology Molecular Function:
hyaluronan synthase activity
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
Keywords:
Chromosomal rearrangement
Complete proteome
Glycosyltransferase
Membrane
Reference proteome
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8798477 15489334 15642402